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5 best apigenin supplements for sleep 2023

5 Best Apigenin Supplement Brands For Sleep in 2023

Apigenin is a bioactive flavonoid, a specific type of plant compound widely recognized for its numerous health benefits. It’s present in various fruits, vegetables, and certain herbs like chamomile. This compound belongs to the class of substances known as phytochemicals, which are basically chemical compounds that occur naturally in plants, contributing to their color, smell, taste, and most importantly, their health-promoting properties.

Sleep and Apigenin: A Natural Connection

Research has pointed to apigenin as a potential aid for improving sleep quality. The link between apigenin and sleep improvement comes from the compound’s ability to interact with the central nervous system, specifically the gamma-aminobutyric acid (GABA) receptors. These receptors play a crucial role in reducing neuronal excitability throughout the nervous system. In simple terms, they help promote calm and reduce stress in the body, setting the stage for a good night’s sleep.

In a 2011 study, researchers discovered that apigenin could bind to these GABA receptors, mimicking the effects of chemicals that reduce activity in the nervous system and help prepare the body for sleep. This suggests that apigenin might have a sedative effect, promoting better sleep quality (Viola et al., 2011).

Other Benefits of Apigenin

Beyond sleep, apigenin has been recognized for a multitude of other potential health benefits:

  1. Anti-Cancer Properties: Apigenin has demonstrated potential anti-cancer properties, with studies showing that it can inhibit the growth and spread of cancer cells (Shukla & Gupta, 2010).
  2. Anti-Inflammatory: Research has indicated that apigenin can help manage inflammatory conditions due to its ability to inhibit pro-inflammatory cytokines (Patel et al., 2007).
  3. Antioxidant Activity: Apigenin has been shown to have antioxidant properties, meaning it can neutralize potentially harmful free radicals in the body (Salehi et al., 2019).
  4. Cardiovascular Health: Some studies have suggested that apigenin may help reduce blood pressure and improve overall heart health (Du et al., 2018).
  5. Neuroprotective Effects: Preliminary research has shown that apigenin could have neuroprotective effects, potentially aiding in the prevention of neurodegenerative disorders (Zhao et al., 2011).

A Closer Look: Apigenin Supplements Review

When considering the addition of apigenin supplements to your daily regimen, there are several reliable brands that come to mind: Toniiq, Nootropics Depot, Codeage, Double Wood, and Momentous Supplements. Let’s break down what each one offers:

Nootropics Depot best apigenin supplements for sleep

Nootropics Depot

Nootropics Depot is well-regarded in the world of cognitive enhancement supplements, or nootropics. They extend their expertise to their apigenin product as well. They believe in the importance of stringent quality control and third-party testing, making their products reliable and trustworthy. Their apigenin supplement is offered in powder and capsule form, giving users the flexibility to adjust based on individual needs. Pricing is competitive, making it a good choice for those who are budget-conscious but still want a reliable product.


Toniiq best apigenin supplements for sleep


Toniiq, a health supplements brand that prides itself on using ultra-high quality ingredients, offers an apigenin supplement that sets a high bar. They highlight their rigorous testing process, aiming to ensure the purity and potency of their products. The company’s apigenin supplement comes from premium sources, ensuring a high concentration per serving, which is essential for users looking for effectiveness. The pricing, while on the higher end, reflects their commitment to quality and potency.


Codeage Liposomal best apigenin supplements for sleep


Codeage positions itself as a brand providing cutting-edge food-based supplements. They emphasize combining traditional techniques with modern science to create superior nutritional products. Their apigenin supplement is unique because it is combined with other bioflavonoids and neuro-nutrients, potentially offering a broader range of health benefits. The pricing is moderate, reflecting the enhanced formulation of their product.


Double Wood best apigenin supplements for sleep

Double Wood

Double Wood, a US-based supplements company, focuses on affordability without compromising quality. They offer a pure, potent apigenin supplement in capsule form. All their supplements are tested for quality and purity by third-party labs, ensuring the safety of their products. Their pricing is quite competitive, offering good value for those who want a straightforward, no-frills apigenin supplement.


Momentous Best apigenin supplements for sleep

Momentous Supplements

Momentous Supplements, a company that values purity and effectiveness, brings a potent apigenin supplement to the table. They stand out with their commitment to transparent sourcing and high-quality, natural ingredients. Their apigenin supplement is vegan-friendly, gluten-free, and non-GMO, catering to a wide range of dietary needs and preferences. The pricing reflects their commitment to high quality and ethical sourcing.


Andrew huberman 5 best apigenin supplement for sleep 2023

Andrew Huberman’s Sleep Stack

Andrew Huberman, a respected neuroscientist at Stanford University, has gained considerable attention for his work and insights into human brain function, especially regarding sleep. In his quest to optimize sleep quality and recovery, Huberman has recommended a specific “sleep stack”, a combination of supplements intended to work synergistically to promote restful sleep. Apigenin figures prominently in this stack, but let’s take a closer look at the full picture.

Huberman’s recommended sleep stack includes:

  1. 144mg of Magnesium L-Threonate / 200mg Magnesium Glycinate: Both forms of magnesium are known for their superior bioavailability and ability to cross the blood-brain barrier. Magnesium is crucial for many bodily functions and is known for its role in promoting relaxation and improving sleep quality.
  2. 50mg Apigenin: As discussed earlier, apigenin is a plant flavonoid that may promote better sleep quality by interacting with GABA receptors in the nervous system, which help to reduce stress and promote calm.
  3. 100-400mg L-Theanine: An amino acid commonly found in tea leaves, L-Theanine can promote relaxation without causing drowsiness. It can boost levels of calming brain chemicals and reduce levels of chemicals linked to stress and anxiety.
  4. 2g of Glycine (3-4 nights a week): Glycine is an amino acid that may improve sleep quality. It can lower your core body temperature, a factor which signals your body that it’s time to sleep.
  5. 100mg of GABA (3-4 nights a week): GABA (gamma-aminobutyric acid) is a naturally occurring amino acid that works as a neurotransmitter in your brain. It’s essential for promoting sleep and can contribute to deeper, more restful sleep.

By combining these supplements, Huberman’s sleep stack aims to cover multiple bases in promoting restful and restorative sleep, from promoting relaxation and reducing anxiety to helping regulate the body’s natural sleep hormones. While this combination is considered safe for most people, always consult with a healthcare professional before starting any new supplement regimen.

Remember, while this combination is generally safe for most people, individual needs and responses can vary, and it’s always wise to consult with a healthcare professional before starting any new supplement regimen.


In choosing an apigenin supplement, it’s essential to take into account the company’s values, quality control measures, the uniqueness of their formula, and price. Whether you’re looking for a pure, potent supplement like Toniiq’s or Double Wood’s offerings, a versatile powdered form from Nootropics Depot, or a complex formulation like Codeage’s, there’s a product out there to suit your needs. Apigenin’s potential to improve sleep quality, alongside its other potential benefits, makes it a compound of interest in the wellness and health field. As always, before adding a new supplement to your routine, it’s best to consult with a healthcare professional. Happy sleeping!

Frequently Asked Questions

You’ve got questions, we’ve got answers. Let’s dive into some of the most commonly asked questions about apigenin.

What are the best natural sources of apigenin?

Apigenin is found in many fruits and vegetables. Some of the best sources include parsley, celery, chamomile tea, and oranges. Consuming these foods and beverages in your daily diet can help increase your intake of apigenin.

Is it safe to take apigenin every day?

While apigenin is generally safe for most people when consumed in food, taking it as a supplement should be done under guidance from a healthcare professional. Current research does not indicate any serious side effects from daily apigenin use, but everyone’s body responds differently to supplements. It’s always a good idea to start with a lower dosage and monitor your body’s response before increasing the dosage.

Is apigenin worth taking?

The potential benefits of apigenin, such as its ability to improve sleep quality and its anti-inflammatory and antioxidant properties, make it an intriguing supplement. However, its effectiveness can vary from person to person, depending on various factors like individual health status, lifestyle, and diet. As always, it’s recommended to consult a healthcare professional before beginning any new supplement regimen.

How many mg of apigenin should you take per day?

There isn’t a universally recommended dosage for apigenin as it can depend on several factors including age, overall health, and specific health goals. Some supplement brands suggest dosages around 50-100 mg per day. However, for a more personalized dosage recommendation, it’s best to consult with a healthcare professional.

Can you take too much apigenin?

While apigenin is generally considered safe, like any supplement, it’s possible to take too much. Overdoing it can potentially lead to negative side effects. While research is limited, high doses may cause side effects like sedation. As always, it’s best to follow the recommended dosage on the product label or the advice of a healthcare professional.

Is apigenin safe for the liver?

Current research suggests that apigenin is safe for the liver, and some studies even suggest that it may have protective effects. For instance, a study published in “The International Journal of Molecular Sciences” suggested that apigenin could protect against liver injury by reducing inflammation and oxidative stress (Ye et al., 2020). However, individuals with pre-existing liver conditions should consult with a healthcare professional before starting any new supplement regimen.

Should I take apigenin in the morning or at night?

Apigenin is known for its calming effects, so it’s often taken in the evening or at night to promote better sleep quality. However, it can be taken at any time of the day depending on individual needs and responses. Always follow the instructions on the supplement label or the advice of a healthcare professional.

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