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Lion's Mane for ADHD And Non-Pharmacological ADHD Treatment

Lion’s Mane for ADHD And Non-Pharmacological ADHD Treatment

In our perpetual quest for mental clarity, increased focus, and a balanced state of mind, we often find ourselves stepping outside the realm of conventional pharmacological treatment, particularly when it comes to managing Attention-Deficit/Hyperactivity Disorder (ADHD). As the wellness industry grows and evolves, the value of natural alternatives has become increasingly apparent. One such alternative, which is garnering significant attention, is the supplement derived from the Lion’s Mane mushroom. This article explores how Lion’s Mane and, in particular, its combination with microdoses of psilocybin in the ‘Stamets Stack’, may offer potential benefits for those living with ADHD.

Understanding ADHD

ADHD is a neurological condition typically characterized by symptoms such as impulsivity, hyperactivity, and inattention. These symptoms can create challenges in daily life, affecting performance at work, school, and in relationships. According to the American Psychiatric Association, ADHD affects about 5% of children, and about half of them will carry those symptoms into adulthood[1].

Traditionally, ADHD is treated with a combination of behavioral therapy and medication, specifically stimulant and non-stimulant medications. These medications work by increasing the levels of certain neurotransmitters in the brain to help improve concentration and focus. However, they also come with potential side effects, including sleep problems, decreased appetite, mood swings, and heart issues[2].

Lion's Mane for ADHD And Non-Pharmacological ADHD Treatment

What is Lion’s Mane?

Lion’s Mane (Hericium erinaceus) is a type of mushroom that has been used for centuries in traditional Chinese medicine for its potent health benefits. It’s aptly named for its unique appearance, resembling the mane of a lion. The benefits of Lion’s Mane are attributed to its bioactive compounds, such as hericenones and erinacines, which have neuroprotective and neuroregenerative properties[3]. And just to be clear, since some people still question whether or not Lion’s Mane is psychedelic, the answer is a resounding no.

Studies suggest that Lion’s Mane may enhance cognitive function, reduce depression and anxiety, and help regenerate neurons[3]. However, what has caught the eye of researchers and holistic health practitioners in recent years is its potential in managing ADHD.

Lion’s Mane for ADHD

Preliminary studies have suggested that Lion’s Mane can stimulate the synthesis of Nerve Growth Factor (NGF), a protein that plays a critical role in the maintenance, survival, and regeneration of neurons[4]. By promoting the growth and branching of neurons, NGF can potentially help enhance cognitive functions like memory, learning, and attention – the areas often affected in ADHD[5].

A 2018 study on mice demonstrated that Lion’s Mane could improve memory and object recognition, possibly making it an effective natural supplement for cognitive enhancement[6]. However, human studies are needed to confirm these effects and determine the optimal dosage.

Lion's Mane for ADHD And Non-Pharmacological ADHD Treatment Paul stamets

The ‘Stamets Stack’: Lion’s Mane and Psilocybin for ADHD and Cognition

Named after famed mycologist Paul Stamets, the ‘Stamets Stack’ combines Lion’s Mane, psilocybin, and niacin. In this stack, psilocybin – a compound found in ‘magic mushrooms’ – is used in microdoses, i.e., sub-perceptual doses that don’t cause hallucinogenic effects.

Emerging research indicates that microdosing psilocybin could have potential cognitive and mental health benefits. A 2019 study suggested that microdosing psilocybin might improve psychological well-being and creativity while reducing symptoms of anxiety and depression[7].

When combined in the ‘Stamets Stack’, the cognitive enhancing effects of Lion’s Mane and the potential mood-enhancing effects of psilocybin could provide a comprehensive approach to managing ADHD symptoms. However, given the early stage of the research and the regulatory status of psilocybin, it’s crucial to seek advice from a healthcare provider before trying this combination.

A Word of Caution

While the Lion’s Mane mushroom shows promise in managing ADHD, it’s essential to approach it as a supplement, not a substitute, for conventional treatment until more definitive research is available. Always consult with a healthcare provider before making significant changes to your ADHD management plan, particularly if it involves substances like psilocybin, which are not universally legal or regulated.

Concluding Thoughts

As we continue to explore the intersection of natural wellness and cognitive function, Lion’s Mane, and its combination with psilocybin in the ‘Stamets Stack’, present an exciting frontier for potential ADHD management. Although the research is in its infancy, the possibilities for providing relief from ADHD symptoms in a natural and holistic way are promising. As science continues to unlock the secrets of these natural substances, the door to new, less invasive, and more harmonious treatments for ADHD will open wider.


  1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.).
  2. Storebø OJ, Ramstad E, Krogh HB, et al. (2015). Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD). Cochrane Database Syst Rev.
  3. Friedman M. (2015). Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. J Agric Food Chem.
  4. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res.
  5. Alnaqeeb MA, Thomson M, Bordia T, Tsai AC, Khan M. (2003). Histopathological changes in the brain of young and adult rats treated with lead: a light and electron microscopic study. Hum Exp Toxicol.
  6. Brandalise F, Cesaroni V, Gregori A, et al. (2017). Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice. Evid Based Complement Alternat Med.
  7. Prochazkova L, Lippelt DP, Colzato LS, Kuchar M, Sjoerds Z, Hommel B. (2018). Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting. Psychopharmacology (Berl).

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