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NMN & Resveratrol: Before and After – My 6-Month Experience

I’ve been on a 6-month journey with Renue By Science’s NMN and Trans Resveratrol, and I’ve been eagerly sharing my experience with anyone and everyone who will listen. If you’ve been considering these supplements for a while, here’s a comprehensive before-and-after to help you make up your mind.

What are NMN and Resveratrol?

First off, let’s demystify these two. NMN stands for Nicotinamide Mononucleotide. It’s a molecule that’s got the wellness community talking about its potential benefits for cellular energy and longevity. Resveratrol is another interesting compound, naturally occurring in grapes and red wine, and it has been linked to longevity and improved cardiovascular health [1].

David Sinclair: The Man Behind the NMN & Resveratrol Buzz

If you’ve delved into the world of anti-aging, cellular health, or even just supplements in general, you’ve probably come across the name David Sinclair. A professor at Harvard Medical School and co-director of the Paul F. Glenn Center for Biology of Aging Research, Sinclair has been a vocal advocate for the potential benefits of NMN and Resveratrol.

The Sinclair Effect

David Sinclair isn’t just a scientist; he’s also a communicator, bridging the gap between complex scientific theories and public understanding. It’s hard to ignore the “Sinclair Effect” on the popularity of these supplements. His research and vocal advocacy have turned them into almost household names for those interested in wellness and longevity.

What Sinclair Says

Sinclair often discusses the science of aging at a cellular level and how compounds like NMN and Resveratrol can potentially slow down or even reverse certain aging processes. One of his key points revolves around the concept of ‘sirtuins’, proteins that regulate cellular health. Resveratrol, according to Sinclair, acts as a sirtuin activator, which in layman’s terms means it could help keep your cells youthful.

As for NMN, Sinclair points to its role as a precursor to NAD+, which is crucial for various cellular functions including DNA repair and energy metabolism.

A Catalyst for Conversation

Whether you’re skeptical or convinced, there’s no denying that David Sinclair has sparked a broader conversation about aging, cellular health, and the role of supplements. And that conversation is essential; it propels research further, inviting more rigorous scientific scrutiny and public interest.

So, when considering NMN and Resveratrol as part of your wellness journey, it might be worth looking into the Sinclair-backed science, but don’t forget to approach it with a balanced perspective.

The benefits of NMN and Resveratrol

When it comes to understanding the benefits of NMN and Resveratrol, we need to dig a bit into the science. Though the research is still evolving, current findings are promising. So, let’s break it down.


NMN, or Nicotinamide Mononucleotide, serves as a precursor to NAD+ (Nicotinamide Adenine Dinucleotide). NAD+ is crucial for cellular energy production. But NMN goes beyond just giving you that quick energy boost. Studies suggest that it also has potential anti-aging properties, specifically in enhancing cellular repair processes [1].

Cardiovascular Benefits

Research indicates that NMN has a positive impact on cardiovascular health. It has been shown to improve vascular smooth muscle tone and endothelial function, thereby potentially reducing the risk of heart disease [5].

Cognitive Function

As we age, cognitive decline is almost inevitable. NMN has been studied for its neuroprotective effects, suggesting it may offer benefits for brain health and cognitive function [6].


Resveratrol is often heralded for its antioxidant capabilities. These antioxidants combat oxidative stress, which contributes to the aging process and various diseases.

Anti-Inflammatory Effects

Inflammation is a natural response to stress or injury, but chronic inflammation can be detrimental. Resveratrol has anti-inflammatory properties, which make it an attractive option for holistic wellness [7].

Improved Insulin Sensitivity

Resveratrol has shown promise in improving insulin sensitivity, which is crucial for metabolic health. Some studies even suggest that it may have potential benefits for individuals with type 2 diabetes [8].

Synergistic Effects

What’s even more interesting is the potential synergy when NMN and Resveratrol are taken together. Some theories suggest that while NMN boosts NAD+ levels, Resveratrol activates Sirtuins, a class of proteins that use NAD+ to regulate cellular health [9].

While these benefits are backed by scientific studies, it’s important to note that individual experiences may vary. These supplements are exciting components in the evolving field of health and wellness, but they are just that—components in a broader lifestyle strategy.

Early Impressions: Weeks 1-4

Just days into starting the supplements, it felt like someone had flipped a switch. My energy levels saw a noticeable bump, and when it came to cardio, it was like I had unlocked a whole new level. I was definitely impressed, but still maintained a healthy degree of skepticism. Read here about how long it takes NMN to start working.

A Reality Check

As we navigate the wellness landscape, it’s essential to approach it with a balanced perspective. While I felt an undeniable boost, it’s crucial to acknowledge that individual reactions to supplements can vary widely. So, in spite of the early promise, I knew it was vital to keep a balanced outlook.

Hitting the 6-Month Mark: The Gains and the Holds

Six months in, and here’s what I can tell you: the energy levels have stayed up, and my post-workout recovery times have improved dramatically. But the real standout has been in the realm of cardio; the improvements there are too significant to ignore. Are NMN and Resveratrol solely responsible? Well, I actually did a control test where I stopped taking NMN for a short period of time to try and verify what kind of difference it made if any.

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While I’ve experienced some marked benefits—boosted energy, better cardio, quicker recovery—it’s essential to remember that wellness is not a one-size-fits-all endeavor. My story is just one data point in a sea of experiences, and what works for me may not be your golden ticket. Heck, for a while, I even stopped taking NMN to really weigh its influence on my well-being.

This journey has been akin to traveling down a road that’s still under construction—thrilling but uncertain. There are scientific checkpoints along the way (thanks to researchers like Sinclair) and anecdotal landmarks that offer some guidance, yet the road is continually evolving. Today’s revelations might be eclipsed by tomorrow’s discoveries.

We’re essentially pioneers in this emerging frontier of cellular health and longevity. That’s exhilarating but also warrants cautious optimism. It’s crucial to continually reevaluate the map, questioning not just the scientific community but also our bodily experiences and responses to these supplements.

As I reflect on these six months, my main takeaway is that balance is key. NMN and Resveratrol have certainly added a fascinating layer to my wellness strategy, but they’re just part of a holistic approach that includes diet, exercise, and mental well-being. And just like you wouldn’t put all your financial hopes into a single stock, diversifying your wellness portfolio is wise.

So, if you’re considering embarking on this journey, do so with both enthusiasm and skepticism. Dive into the research, consult with healthcare professionals, and most importantly, listen to your own body. Your path in the sprawling, complex terrain of wellness is yours to carve, informed by science but validated by your own lived experience.


  1. Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule.
  2. Resveratrol in Cardiovascular Disease: What Is Known from Current Research?
  3. Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner
  4. The Sirtuin family’s role in aging and age-associated pathologies.
  5. Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism
  6. Nicotinamide Mononucleotide Attenuates Brain Injury After Intracerebral Hemorrhage by Activating Nrf2/HO-1 Signaling Pathway.
  7. Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease
  8. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials
  9. Resveratrol improves health and survival of mice on a high-calorie diet

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