5 Best Methylated Multivitamin Supplements

The 5 Best Methylated Multivitamin Supplements (2024)


  1. Best value for ingredients included – 10X Optimize Methylated Multivitamin
  2. Best simple & straightforward complex – Methyl-Guard Plus by Thorne
  3. Best comprehensive & plant-based – Phytomulti by Metagenics
  4. Best simple multivitamin – Methylpro Mutlivitamin
  5. Best minimal blend – MethylAssist by Pure Encapsulations

Methylation is one of those words that sounds like it belongs in a science lab rather than in our everyday lives. But the reality is that this biochemical process plays a crucial role in maintaining our health and well-being. From influencing gut and mental health to hormones, methylation is an unsung hero in our bodily functions. Understanding this process and how to optimize it can be a game changer, especially for those interested in holistic health and wellness.

10x genetic methylation testing

What is Methylation?

Before we discuss the best methylated multivitamins, let’s define methylation. In simple terms, it’s a process in which a methyl group (one carbon atom bound to three hydrogen atoms) is transferred from one molecule to another. This seemingly small action has massive implications, affecting everything from heart health to sleep cycles, libido, and mental well-being.

The MTHFR Gene Mutation and Its Impact

An interesting aspect of methylation is its relationship with the MTHFR gene mutation. Approximately 44% of the population carries this mutation, which can hinder the body’s ability to convert vitamins, like B9 (folic acid), into their active forms. This can lead to various health issues, from fertility problems to mental health concerns. Understanding whether you’re affected by this mutation is vital in tailoring your supplement intake for optimal health.

@eternalwellness100 Why everyone should get a genetic methylation test. #garybrecka #nmnsupplement #genetest ♬ original sound – Eternal Wellness

The Importance of Methylated Vitamins

Choosing the right form of vitamins is critical for those with the MTHFR mutation or anyone seeking to optimize their methylation process. This is where methylated multivitamins come into play. They provide vitamins in their active forms, which are more readily usable by the body, especially for those with methylation issues.

How Methylation Affects Overall Health

Cellular and Genetic Implications

Methylation is intricately linked with our genetic expression and cellular function. DNA methylation, for example, plays a role in turning genes on and off, impacting everything from physical traits to personalities.

The Link with Diseases

Poor methylation can lead to a range of health issues, including nervous system problems, gut dysbiosis, thyroid dysfunction, and even heart issues. While genetic testing can offer some insights, focusing on diet, exercise, stress levels, and other lifestyle factors is often more effective.

Supplements for Improved Methylation

Beyond multivitamins, there are other supplements that can support methylation:

  • Coenzyme Q10: Known for heart health and anti-aging, CoQ10 also aids in methylation, as shown in studies like one focusing on breast cancer patients.
  • Phosphatidylcholine: This compound supports healthy homocysteine levels and contributes to choline production, indirectly affecting methylation.
  • Folinic or L-Methylfolate: Essential for those with the MTHFR gene mutation, these forms of folate are more easily utilized by the body.
  • Vitamin B-6 and B-12: These vitamins are crucial for overall well-being and are part of a chain reaction essential for methylation.
@the.frequency.alchemist Link in bio for some Health essentials and tips ️👋 share, like, #methylatedbvitamins #healthtips #wellnesstiktok #fyp #foryou #health #garybrecka ♬ Natural food, cooking and recipes, cooking background music(1324745) – MATSU

The Top 5 Methylated Multivitamins

The 5 Best Methylated Multivitamin Supplements 10x optimize


#1 10X Optimize by 10X Health

Regular Price: $37.80 (Sale: $42.00 USD)

Why Choose 10X Optimize?:

  • It’s a full-spectrum multivitamin with the most bioavailable forms of each vitamin
  • Large and adequate dosing of each ingredient averaging over 100% DV
  • Reasonable price relative to the competition and value you get considering the broad ingredients list
  • Backed by trusted thought leader Gary Brecka and taken by popular figures such as Dana White
  • Further enhanced by Genetic Methylation Testing provided by 10X Health

Gary Brecka, the Chief Human Biologist for 10X Health, has been instrumental in bringing the science of methylation to the forefront of wellness discussions. With over two decades of experience in biohacking and functional medicine, Brecka has become a prominent figure in the wellness world. His expertise in serum blood and genetic biomarkers has gained attention on platforms like the Joe Rogan Experience and transformed the health of notable figures like Dana White, helping reverse severe health issues, including obesity, sleep apnea, high blood pressure, and high triglycerides.

A Blend of Science and Wellness

10X Optimize is not just a multivitamin; it’s a meticulously crafted formula designed to target specific DNA and genetic deficits in your individual methylation pathway. This includes key components like methylated folic acid (5-MTHF), riboflavin (B2), pyridoxine (B6), methylated B12, magnesium, and zinc. Additionally, it contains N-acetyl L-cysteine (NAC), renowned for its support in the methylation pathway. This comprehensive blend ensures that your body receives the essential nutrients it needs for optimal performance.

Key Ingredients and Benefits:

  • Riboflavin (Vitamin B2): Riboflavin is vital for energy production and cellular function. In the context of methylation, it plays a crucial role in the conversion of homocysteine to methionine, a key methylation process in the body. This helps maintain a healthy balance of these amino acids, which is crucial for cardiovascular and neurological health.
  • Vitamin B6 (Pyridoxine): Pyridoxine is integral in amino acid metabolism and neurotransmitter synthesis. It assists in the methylation cycle by converting homocysteine to cysteine, which is then used to produce glutathione, the body’s primary antioxidant. This process is essential for detoxification and protecting cells from oxidative stress.
  • Folate (as L-5-Methyltetrahydrofolate Calcium): This form of folate is the bioactive version of vitamin B9, essential for DNA synthesis and repair. In methylation, it provides methyl groups required for converting homocysteine back into methionine, supporting cardiovascular, neural, and mental health.
  • Vitamin B12 (as Hydroxycobalamin): Hydroxycobalamin is a natural form of vitamin B12 that plays a pivotal role in brain and nervous system function. It works synergistically with folate in the methylation process to convert homocysteine to methionine, which is crucial for DNA synthesis and red blood cell formation. Each of these components in 10X Optimize is carefully selected for its specific role in supporting the methylation pathways, thereby promoting overall health and well-being.

The Mission and Philosophy of 10X Health System

The 10X Health System is a movement to redefine health and wellness globally. Its approach challenges the norms of modern medicine by focusing on patient-centric, individualized wellness journeys. The 10X movement is about action, accountability, and achieving optimal wellness through restoration, cellular repair, and regeneration.

Their Commitment to You:

  • Results-Driven Approach: 10X Health System focuses on tangible outcomes and aims to empower individuals in their wellness journey.
  • Expert Team: The 10X team consists of medical professionals and wellness experts who are dedicated to providing top-tier health solutions.
  • Customized Wellness: Recognizing the uniqueness of each individual, 10X Health offers personalized health strategies to meet your specific needs.
The 5 Best Methylated Multivitamin Supplements thorne methyl-guard


Use code INTELLIGENT for 20% off your entire order

#2 Methyl-Guard Plus by Thorne

Methyl-Guard Plus by Thorne – $56 for 90 Capsules

Why Choose MethylGuard Plus?:

  • It is NOT a full-spectrum multivitamin and focuses almost exclusively on methylated B vitamin complexes
  • If you want to dose out your vitamins individually, this is the ideal methylated multivitamin for you, as it doesn’t include a full spectrum of ingredients
  • Thorne is a trusted name in quality supplements and third-party testing, ensuring quality ingredients and accurate labeling

Methyl-Guard Plus stands out as a meticulously formulated supplement designed to support heart, blood vessels, brain, and bone health through enhanced methylation. This product is particularly effective for individuals looking to maintain healthy homocysteine levels and support overall cardiovascular, cognitive, and bone health.

Key Ingredients and Their Methylation Benefits:

  1. Riboflavin (as Riboflavin 5′-Phosphate Sodium – 90 mg): This active form of vitamin B2 is crucial for methylation processes, particularly in the conversion of homocysteine into methionine, a vital amino acid. This conversion is essential for maintaining cardiovascular and neurological health.
  2. Vitamin B6 (as Pyridoxal 5′-Phosphate – 45 mg): The active form of vitamin B6 is integral in neurotransmitter synthesis and amino acid metabolism. It plays a pivotal role in the methylation cycle by aiding the conversion of homocysteine to cysteine, which is crucial for detoxification and antioxidant defense systems.
  3. Folate (3 mg as L-5-Methyltetrahydrofolate): This bioavailable form of folate is key for DNA synthesis and repair. In methylation, it donates methyl groups necessary for the conversion of homocysteine to methionine, supporting a range of health aspects, including cognitive and neural health.
  4. Vitamin B12 (as Methylcobalamin – 3 mg): Methylcobalamin, an active form of vitamin B12, is essential for brain and nervous system function. It works alongside folate in methylation processes, especially in the conversion of homocysteine to methionine, crucial for DNA synthesis and maintaining healthy red blood cells.
  5. Betaine Anhydrous (Trimethylglycine – 1.8 g): Betaine acts as a methyl donor in the conversion of homocysteine to methionine. It plays a significant role in maintaining a healthy homocysteine level in the blood, which is important for cardiovascular, cognitive, and neurological health.

Thorne’s Mission and Philosophy

Thorne’s ambition is to empower individuals to live healthier, longer lives through personalized scientific testing and solutions. They aim to extend health span, ensuring people feel their best at every age and life stage. With a deep portfolio of individualized offerings, Thorne is dedicated to redefining health and wellness at every life stage.

Thorne’s Commitment:

  • Personalized Wellness: Tailoring solutions to individual health goals and needs.
  • Scientific Foundation: Utilizing testing and research to inform product development.
  • Holistic Health Span Extension: Focusing on comprehensive wellness for a healthier, longer life.

Methyl-Guard Plus by Thorne represents a state-of-the-art approach to methylation support, addressing key biochemical processes for optimal health. Its carefully selected ingredients and Thorne’s commitment to personalized, scientific wellness make it an excellent choice for those seeking to support their methylation pathways and overall well-being.

Thorne discount code
The 5 Best Methylated Multivitamin Supplements optimal multivitamin by Metagenics


#3 Phytomulti by Metagenics

PhytoMulti® – $69.80 for 120 Capsules

Why Choose Phytomulti by Metagenics?:

  • This is another competitive full-spectrum methylated multivitamin. If you don’t like taking multiple pills each day, this might be ideal for you
  • Includes a phytonutrient blend setting it apart from the rest, and also includes Resveratrol, a popular longevity supplement found in red wine
  • Metagenics is a trusted name in quality supplements and third-party testing, ensuring trustworthy ingredient labels

PhytoMulti® by Metagenics is a synergistic blend of essential vitamins, minerals, and a patented array of phytonutrients designed to replenish what modern diets often lack. This advanced formula supports cellular health and healthy aging and promotes the healthy functioning of key body systems for lasting well-being.

Unique Features of Phytomulti:

  1. Methylated Vitamin B6 (as Pyridoxine HCl – 25 mg): This active form of Vitamin B6 is crucial in numerous biochemical reactions, including those in the methylation process, neurotransmitter synthesis, and amino acid metabolism.
  2. Methylated Folate (as Calcium L-5-Methyltetrahydrofolate—1,360 mcg DFE): This formulation provides a bioavailable form of folate, essential for DNA synthesis and repair. It supports methylation, which is especially beneficial for individuals with MTHFR gene variations.
  3. Methylated Vitamin B12 (as Methylcobalamin – 200 mcg): Methylcobalamin, the active form of B12, plays a vital role in brain and nervous system function and is essential in the methylation process, aiding in the conversion of homocysteine to methionine.

Embracing a Holistic Approach to Health

In addition to its focus on methylated B vitamins, PhytoMulti® stands out with its proprietary blend of phytonutrients and plant extracts. This blend is scientifically designed to support cellular health and combat the effects of aging:

  • Patented Phytonutrient Blend: This blend includes citrus bioflavonoids, green coffee bean extract, pomegranate, grape seed extract, and more, which have been clinically shown to support cellular health and healthy aging.
  • Comprehensive Health Support: The formula is enhanced with pure, potent plant extracts and phytonutrients sourced from nature, promoting the healthy functioning of various body systems.

The Metagenics Difference: A Commitment to Innovation and Quality

Metagenics has a long-standing reputation for delivering high-quality, science-based nutritional supplements and medical foods. Their approach is characterized by:

  • Innovative Health Solutions: They are not just creating vitamins but changing the approach to health care, redefining health and wellness.
  • Collaborative Expertise: Working with practitioners across disciplines, Metagenics ensures their products are informed by the latest research and clinical insights.
  • Educational Leadership: Through the Metagenics Institute, they provide cutting-edge educational resources for practitioners and patients alike.

PhytoMulti® by Metagenics offers a unique approach to daily multivitamins, combining essential methylated vitamins with a rich array of phytonutrients. This comprehensive formula supports methylation and cellular health and caters to the overall well-being of the body’s key systems. For those seeking a holistic and scientifically-backed multivitamin, PhytoMulti® represents a blend of nature’s best for optimal health.

The 5 Best Methylated Multivitamin Supplements MethylPro multivitamin


#4 MethylPro Multivitamin

MethylPro Multivitamin – $51.25 for 30 Servings

Why Choose MethylPro?:

  • Another competitive full-spectrum methylated multivitamin. If you don’t like taking multiple pills each day, this might be ideal for you
  • Simple ingredients list that doesn’t include any proprietary blends
  • Includes the most bioavailable forms of vitamins not generally available in their methylated forms

MethylPro Multivitamin is a specially designed one-a-day capsule crafted to meet the nutritional priorities of those in need of high-dose L-methylfolate combined with a well-rounded multivitamin/mineral complex. This supplement is particularly beneficial for individuals who struggle to convert folic acid to its usable, active form due to genetic variations.

Key Ingredients and Their Unique Benefits:

  1. Vitamin B-6 (as Pyridoxal 5’ Phosphate – 10 mg): The active form of Vitamin B-6, essential in various biochemical reactions, including neurotransmitter synthesis and amino acid metabolism. It plays a crucial role in the methylation process and supports overall neurological health.
  2. Folate (as 15 mg from 20.5 mg L-5-Methylfolate, Calcium Salt – 25 mg DFE): A significant dose of bioavailable folate, crucial for DNA synthesis, repair, and the normal production of neurotransmitters. This form of folate is especially important for those with MTHFR genetic mutations, aiding in effective methylation and neurotransmitter production.
  3. Vitamin B-12 (as Methylcobalamin – 1000 mcg): Methylcobalamin, the active form of Vitamin B-12, supports brain and nervous system function and is integral to the methylation process, particularly in the conversion of homocysteine to methionine.

Holistic Health Support Offered by MethylPro Multivitamin

MethylPro Multivitamin goes beyond just providing essential nutrients; it supports various aspects of health:

  • Mood and Energy Support: L-methylfolate aids in producing mood-balancing neurotransmitters, while the B vitamins support cellular energy production.
  • Methylation Support: This process is vital for numerous bodily functions, including neurotransmitter production and liver detoxification. The supplement provides important methyl donors and cofactors like folate, choline, B6, and B12.
  • Immune Support: Ingredients like vitamins A, C, D, and zinc contribute to robust immune function.
  • Nutritional Support: Offering a spectrum of daily nutrients in their most bioavailable forms, it supports balanced mood, energy levels, and overall well-being.

The MethylPro® Commitment to Quality and Innovation

MethylPro® is dedicated to creating supplements that address mental and physical health needs effectively. Their approach is characterized by:

  • Professional Strength Formulations: MethylPro® supplements are manufactured by Metabolic Maintenance®, a company renowned for science-based formulas and high-quality production.
  • Pure and Simple Ingredients: Their products are made with high-quality L-methylfolate without unnecessary additives, ensuring purity and potency.
  • Innovative Research and Development: Their team is dedicated to creating products that provide innovative solutions for healthcare needs.

MethylPro Multivitamin stands out as a comprehensive solution for those seeking a high-quality multivitamin with a focus on methylation support. Its formulation is particularly suited for individuals with specific genetic needs or those looking to enhance mood, energy, and overall health through optimal nutrient intake. For those who prioritize both methylation support and broad-spectrum nutritional wellness, MethylPro Multivitamin represents a blend of science and nature for optimal health.

The 5 Best Methylated Multivitamin Supplements MethylAssist Pure Encapsulations


#5 Methyl Assist by Pure Encapsulations

MethylAssist 90’s – $59.60 for 90 servings

Why Choose Methyl Assist?:

  • A simple methylated multivitamin that doesn’t include a long list of ingredients. Includes only the essential B complex not generally available in their non-methylated forms
  • Simple ingredients list, that doesn’t include any proprietary blends
  • Pure Encapsulations is a highly reputable supplement company that does rigorous third-party testing ensuring safe ingredients

Methyl Assist by Pure Encapsulations is a thoughtfully formulated supplement designed to support healthy methylation, a key biochemical process essential for cardiovascular, neuronal, and emotional health. This supplement provides activated B vitamins to aid in this critical process.

Highlighted Ingredients and Their Impact:

  1. Vitamin B6 (as Pyridoxal 5′ Phosphate – 16 mg): At 941% of the daily value, this active form of Vitamin B6 is essential in a myriad of biochemical reactions. It’s particularly crucial for neurotransmitter synthesis, amino acid metabolism, and supporting the methylation process. Its role extends to maintaining peripheral nerve health and overall neurological function.
  2. Folate (as Metafolin, L-5-MTHF – 1,667 mcg DFE, 1,000 mcg L-5-MTHF): Providing 417% of the daily value, this bioavailable form of folate is directly usable by the body, bypassing genetic variations that may affect folate metabolism. It plays a key role in DNA synthesis and repair, and is vital in the production of mood-balancing neurotransmitters, making it essential for neurological health and emotional well-being.
  3. Vitamin B12 (as Methylcobalamin – 1,000 mcg): With a staggering 41,667% of the daily value, methylcobalamin—the active form of Vitamin B12— is instrumental for brain and nervous system health. It is a key player in the methylation process, particularly in the conversion of homocysteine to methionine, a vital process for cardiovascular and cognitive health.

Emphasizing Pure, High-Quality Ingredients for Optimal Health

Methyl Assist stands out for its dedication to purity and quality, ensuring that each ingredient is free from unnecessary additives and common allergens:

  • Pure and Free from Unnecessary Additives: Methyl Assist is formulated with high-quality ingredients, free from wheat, soy, dairy, eggs, gluten, artificial colors, flavors, sweeteners, and GMOs.
  • Science-Backed Formulation: Backed by research, Methyl Assist is designed to promote healthy endothelial function, support methylation of homocysteine to methionine, and maintain peripheral nerve health and comfort.
  • Allergen Transparency: Pure Encapsulations is committed to transparency, listing every ingredient, even trace amounts, and highlighting any possible allergens.

Pure Encapsulations’ Commitment to Wellness and Sustainability

Pure Encapsulations not only focuses on creating high-quality supplements but also embraces a holistic approach to wellness and sustainability:

  • Collaboration with Medical Professionals: Development of products in close collaboration with leading medical professionals and nutritional experts.
  • Quality Assurance: Sourcing high-quality ingredients, conducting clinical trials, and undergoing additional testing to ensure product purity and potency.
  • Supporting Global Wellness: Proudly supporting non-profit organizations dedicated to global wellness, health improvement, and creating a sustainable future.

Methyl Assist by Pure Encapsulations offers a comprehensive and scientifically sound approach to supporting methylation and overall health. Its focus on pure, high-quality ingredients, backed by verifiable science, makes it a trustworthy choice for those seeking to enhance their cardiovascular, neurological, and emotional health through effective methylation support.

Methylation and Lifestyle: A Holistic Approach

While supplements are important, they’re just one piece of the puzzle. A healthy lifestyle, including a balanced diet and regular exercise, plays a significant role in optimizing methylation. Reducing stress and getting adequate sleep are also key components.


The journey toward optimal health is multifaceted, and choosing the right methylated multivitamin is a crucial part of this path. Each of the supplements we’ve explored — 10X Optimize, Thorne MethylGuard Plus, PhytoMulti by Metagenics, MethylPro Multivitamin, and Methyl Assist by Pure Encapsulations — offers unique benefits tailored to support different aspects of health through effective methylation. Let’s delve into the distinct qualities of each, helping you make an informed choice for your health needs.

10X Optimize by 10X Health

Developed with the expertise of Gary Brecka, 10X Optimize stands out for its comprehensive approach to optimizing bodily functions. It targets specific DNA and genetic deficits in the methylation pathway, making it ideal for those seeking a supplement that goes beyond basic nutritional needs, enhancing heart health, sleep, hormones, and more.

Thorne MethylGuard Plus

Thorne’s MethylGuard Plus focuses on cardiovascular, cognitive, and bone health by maintaining healthy homocysteine levels. Its formulation is especially beneficial for those focused on these specific health areas, providing active forms of B vitamins essential in the methylation process.

PhytoMulti by Metagenics

PhytoMulti by Metagenics distinguishes itself with a blend of essential vitamins, minerals, and a patented phytonutrient array. This supplement is not just about filling nutritional gaps; it’s about enhancing cellular health and healthy aging, making it a great choice for those seeking a holistic approach to health and wellness.

MethylPro Multivitamin

MethylPro Multivitamin is specifically designed for those looking for high-dose L-methylfolate combined with a broad multivitamin/mineral complex. This one-a-day capsule is perfect for individuals with specific genetic needs related to methylation, offering support for balanced mood, reliable energy, and immune health.

Methyl Assist by Pure Encapsulations

Methyl Assist by Pure Encapsulations provides a scientifically-backed formulation that supports cardiovascular, neuronal, and emotional health. It’s designed for individuals seeking a supplement that not only provides essential nutrients but also focuses on purity and quality, free from common allergens and unnecessary additives.

Making an Informed Choice

Each of these methylated multivitamins brings something unique to the table. Your choice should align with your health goals, lifestyle, and nutritional needs. Whether addressing specific health concerns, enhancing overall wellness, or managing genetic predispositions, there’s a supplement in this list that can cater to your requirements.

Remember, supplementation is a part of a larger health picture that includes a balanced diet, regular exercise, and stress management. Always consult with a healthcare professional before starting any new supplement regimen, especially if you have existing health conditions or are on other medications.

In conclusion, the world of methylated multivitamins offers varied and nuanced options to support different aspects of health and well-being. By selecting a supplement that aligns with your unique health profile and needs, you can effectively support your body’s methylation processes, contributing significantly to your journey toward holistic health and vitality.


  1. Genetics Home Reference – MTHFR
  2. National Institutes of Health – Methylation
  3. Journal Study on Coenzyme Q10 and Methylation
  4. Healthline – The MTHFR Mutation
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