does melatonin affect testosterone

Does Melatonin Affect Testosterone? A Comprehensive Look

Melatonin, popularly known as the “sleep hormone,” is commonly used to treat sleep disorders and promote a good night’s rest. While the benefits of melatonin in regulating sleep patterns are well-documented, some studies have pointed to the possibility of melatonin affecting testosterone levels. But is melatonin more likely to cause issues with vitality and testosterone? Let’s explore this complex relationship and offer some alternative recommendations for optimizing sleep.

Melatonin’s Connection with Testosterone

Testosterone is the primary male sex hormone responsible for various functions, including muscle development, mood regulation, and overall vitality. Research around melatonin’s effects on testosterone levels has yielded mixed results, which warrants a closer look.

Melatonin’s Inhibitory Effects

A study conducted by Bayram Yilmaz et al. showed that melatonin inhibits testosterone secretion by acting at the hypothalamo-pituitary-gonadal (HPG) axis in rats [1]. This conclusion was reached by examining the changes in serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone levels in different groups of rats.

Melatonin administration to intact animals significantly decreased both LH and testosterone levels (p<0.01) [1]. The findings suggest a functional relationship and feedback regulation between the pineal gland and the testes, indicating that melatonin could potentially affect testosterone production.

Conflicting Results

However, not all research supports this connection. A study conducted by John Zizzo et al. investigated the impact of low-dose melatonin supplementation on testosterone levels in U.S. adult males[2] . The analysis included 7,656 participants, and interestingly, the study found no association between melatonin intake in the past 30 days and low testosterone levels [2].

This highlights the complexity of the relationship between melatonin and testosterone and indicates that more research is needed to fully understand the connection, especially with varying doses and periods of exposure.

Alternatives for Optimizing Sleep

While the effects of melatonin on testosterone remain a subject of debate, here are some alternative methods to enhance sleep quality without potentially compromising vitality:

  1. Magtein (magnesium l-threonate): A special form of magnesium that has been shown to effectively cross the blood-brain barrier. It may help improve cognitive functions and support healthy sleep patterns.
  2. Magnesium glycinate: Known for its calming effects, magnesium glycinate may promote relaxation and support a more restful sleep.
  3. Exercise: Regular physical activity can lead to deeper, more restorative sleep by improving overall health and reducing stress.
  4. Sun Exposure: Getting enough sunlight, particularly in the morning, can help regulate the body’s internal clock and improve sleep quality.


The relationship between melatonin and testosterone is multifaceted and not entirely clear. While some studies support melatonin’s inhibitory effects on testosterone production, others present conflicting evidence.

If you are considering melatonin supplementation, it might be prudent to consult a healthcare provider and consider alternative methods for optimizing sleep, such as magnesium supplements, regular exercise, and sun exposure. The world of sleep, vitality, and hormones is complex, and personalized recommendations may be best suited to ensure optimal wellness.


  1. Yilmaz, B. et al. (2001). Melatonin inhibits testosterone secretion by acting at hypothalamo-pituitary-gonadal axis in the rat. PMID: 11455362.
  2. Zizzo, J. et al. (2022). Impact of Low-Dose Melatonin Supplementation on Testosterone Levels in U.S. Adult Males. PMID: 35963395, DOI: 10.1016/j.urology.2022.07.048.


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